R&D OUTCOMES
The first successful animal embryo transfer was in Vietnam (1978).The first successful in vitro fertilization and embryo sexing in animals in Vietnam (2002,2003). Application of somatic cell nuclear transfer for conservation of genetic resources of endangered wild species since 2000.
STEM CELL TECHNOLOGY-BIOMEDICINE
CRYOBIOLOGY- CELL & EMBRYO PRESERVATION
The first world successful embryo cryopreservation by rapid freezing after partial dehydration at room temperature (1983). The first baby from cryopreservation semen in Vietnam (1999)
ADVANCED REPRODUCTIVE BIOTECHNOLOGY
DIGITAL INTEGRATION
Stem cell isolation, characterization, expantion and standardization. Production of animal embryonic stem cells, human mensenchymal stem cells; production of cardiac, neural stem cells by in vitro differentiation (2002, 2007. 2015).
Science & Technology Potentials
Interdisciplinary integration of informatics and biotechnology for developing a new strategy of in situ-ex situ combined biodiversity conservation, developing a model of digital farming, upgrading the level of automated real-time monitoring for cell cryobanking, cell culture and therapy.
Milestones Achievements
SABC is initiated and led by experienced experts in the field of modern embryonic biotechnology, updating the world's technology progress following embryo transfer, embryo cryopreservation, in vitro embryo production, and somatic cloning in the 80s and 90s of the twentieth century to today’s cutting-edge stem cell and gene-based innovation
SABC experts are the authors of pioneering works on innovative research and transfer of reproductive and stem cell technology in Vietnam.
> Pioneering research in embryo biotechnology, achieving the first successful embryo transfer in an experimental animal in 1978 and a domestic animal in 1986. Notably, in 2002, we achieved a breakthrough with the first successful production and transfer of in vitro fertilization and sexing embryos ( Nguyen B X, 2006).
> Advancements in cryobiology, including the world's first groundbreaking achievement of successful rapid freezing of embryos after dehydration at room temperature in 1983 (Nguyen et al 1983, 1984; JP Renard et al, 1984) and the first successful vitrification of somatic cloning embryos in 2000 ( Nguyen et al, 2000). The successful cryopreservation of fish embryo in 2010.
> Leading the way in human-assisted reproductive technology, with the initiation of the first successful semen cryobanking and its application for infertility treatment in 1999.
> Pioneering research in somatic cloning and cell reprogramming, marked by the first successful application of interspecies somatic cell nuclear transfer in wild endangered animal species Saola-Nghetinhensis Prodoryx, native minipig and monkey species for biomedical research during the years 1998-2000.
> Significant contributions to stem cell biotechnology, achieving the first successful cryopreservation and differentiation of MSC cells during the period of 2008-2010.
> Implementing stem cell cryobanking technology and clinical application with hematology and blood transfusion hospitals, obstetrics hospitals and cancer hospitals - a premise for updating cutting-edge new C&G technologies.
SABC experts and collaborators have chaired and participated in many national and international projects working on the application of technological innovations for improving biodiversity conservation, livestock development and for biomedicine.
Research projects
National projects R&D in Embryo Biotechnology (470107, 1980-1985; 52D-0113,1986-1990;KC-08-16); Vietnam National Foundation for Science and Technology Development (NAFOSTED) project on somatic cloning;
project of cooperation with AIRE Development and INRA French on cryobiology and embryo preservation, embryo transfer; project for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN), Japan for somatic cloning and vitrification cryopreservation; Vietnam_Italy Project on development of reproductive technology in buffalo; Vietnam-USA project on in vitro fertilization sexing and intercontionental embryo transfer.
MOST Project ĐTĐL 2007/03 for differentiation of human umbilical cord matrix stem cell into neural and cardiac progenitor cells; Viet-Thailand project on induction of corneal epithelial cells;
https://rep.bioscientifica.com/view/journals/rep/71/2/jrf_71_2_032.xml?rskey=b49amE&result=4; https://pubmed.ncbi.nlm.nih.gov/16725971/
DOI: 10.1016/0093-691x(84)90459-x
https://pubmed.ncbi.nlm.nih.gov/10898213/
https://www.publish.csiro.au/rd/RDv19n1Ab93
https://pubmed.ncbi.nlm.nih.gov/25474756/
Transfer technology and Development project
Project supported by AIRE-Developpement (International Agency for Research and Study for Development, French), INRA French, Bomed-USA for implementation of embryo biotechnology in domestic animal breeding.
Project Biodiva Supported by FSP (Fonds de solidarité prioritaire), FFEM (Fonds français pour l'environnement mondial), CIRAT Centre de Coopération Internationale en Recherche Agronomique pour le Développement) and INRA for "Inventory, characterization and promotion of domestic animal biodiversity and wilderness of the Annamitic Cordillera in Vietnam, for conservation and sustainable development", improvement of somatic Cloning of wild Saola and Gaur, cryobank management and development of in situ - ex situ links.
JSPS-Japan-VAST Vietnam Project for application vitro production, manipulation and preservation of porcine embryos of Vietnam's native pig breeds for the conservation of biodiversity in pigs.
Project 01C-05/04-2016-3, supported by HanoiDOST. Main objective: Developing technique of reproductive management for improving rabbit production.
https://pigtrop.cirad.fr/content/download/2581/13171/file;https://www.publish.csiro.au/RD/RDv16n1Ab259;https://www.publish.csiro.au/rd/ExportCitation/rdv17n2ab56; https://www.publish.csiro.au/RD/RDv16n1Ab259)
https://123dok.net/article/la-production-scientifique-et bibliographique.qvl9g9ng;
https://agris.fao.org/agris-search/search.do?recordID=FR2013104863